Article
Power of affected sibling method tests for linkage.
Human heredity - 1 Jan 2000
Tierney C, McKnight B
Abstract excerpt
When the mode of inheritance of a disease susceptibility (DS) gene is unknown, the affected sibling method can be applied to study whether a DS gene and a marker gene are linked. This method considers how k affected siblings (k > or = 2) share marker alleles identically by descent from their pare...
Topics
- Alleles
- Computer Simulation
- Disease Susceptibility
- Genetic Diseases, Inborn
- Genetic Linkage
- Genetic Markers
- Humans
- Likelihood Functions
- Models, Genetic