Article
Multipoint linkage analysis of the pseudoautosomal regions, using affected sibling pairs.
American journal of human genetics - 1 Aug 2000
Dupuis J, Van Eerdewegh P
Abstract excerpt
Affected sibling pairs are often the design of choice in linkage-analysis studies with the goal of identifying the genes that increase susceptibility to complex diseases. Methods for multipoint analysis based on sibling amount of sharing that is identical by descent are widely available, for both...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human
- Computer Simulation
- Diabetes Mellitus, Type 1
- Female
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Humans
- Lod Score
- Male
- Matched-Pair Analysis
- Models, Genetic
- Multifactorial Inheritance
- Nuclear Family
- Quantitative Trait, Heritable
- Reproducibility of Results
- Research Design