Article
Linkage analysis of Genetic Analysis Workshop 12 simulated data based on affected individuals only.
Genetic epidemiology - 1 Jan 2001
Cordell H J, Dudbridge F
Abstract excerpt
A variety of allele-sharing methods was used to assess linkage to disease for a whole-genome screen in each of ten replicates from the Genetic Analysis Workshop 12 simulated data. Analysis of each replicate produced many false positive results in addition to a few "true" positives. Conditioning on the strongest initial linkage and reanalyzing using a variety of conditional methods did not improve the power for...
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