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Article

Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease.

Circulation - 14 Dec 1999

Mager A, Lalezari S, Shohat T, Birnbaum Y, Adler Y, Magal N, Shohat M

Abstract excerpt

BACKGROUND: Homozygosity for the common (677C-->T) mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with hyperhomocysteinemia, but there is uncertainty as to the association between this mutation and coronary artery disease (CAD). This study examined the association between MTHFR genotypes and age at onset of CAD. METHODS AND RESULTS: Patients (n=169) with documented myocardial...

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Source

Identifiers

PMID: 10595952
DOI: 10.1161/01.cir.100.24.2406

Genes

CAD
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease.PMID 10595952Read ↗

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Identification of six methylenetetrahydrofolate reductase (MTHFR) genotypes resulting from common polymorphisms: impact on plasma homocysteine levels and development of coronary artery disease.Semantic proximity Read ↗

Homozygosity of the TT methylenetetrahydrofolate reductase C677T genotype is an independent long-term predictor of cardiac death in patients with premature myocardial infarction.Semantic proximity Read ↗

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The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels.Semantic proximity Read ↗

Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation.Semantic proximity Read ↗

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