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Article

Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 1996

Wilcken D E, Wang X L, Sim A S, McCredie R M

Abstract excerpt

Modest elevations of circulating homocyst(e)ine are common in patients with vascular disease. We explored in normal and coronary artery disease (CAD) populations the distribution of a mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene that results in enzyme thermolability and r...

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Source

Identifiers

PMID: 8673563
DOI: 10.1161/01.atv.16.7.878

Genes

CAD
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8673563-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation.PMID 8673563Read ↗

A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction.Semantic proximity Read ↗

A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction.Semantic proximity Read ↗

Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism (C-677T) and coronary artery disease.Semantic proximity Read ↗

Association of polymorphism in the thermolabile 5, 10-methylene tetrahydrofolate reductase gene and hyperhomocysteinemia with coronary artery disease.Semantic proximity Read ↗

Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.Semantic proximity Read ↗

Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental interaction.Semantic proximity Read ↗

Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and the risk of coronary artery disease.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene and coronary artery disease.Semantic proximity Read ↗

A low prevalence of the C677T mutation in the methylenetetrahydrofolate reductase gene in Asian Indians.Semantic proximity Read ↗

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