Article
Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.
American journal of medical genetics - 1 Jun 2001
Szczeklik A, Sanak M, Jankowski M, Dropiński J, Czachór R, Musiał J, Axenti I, Twardowska M, Brzostek T, Tendera M
Abstract excerpt
Diminished activity of 5,10 methylenetetrahydrofolate reductase (MTHFR), a regulatory enzyme of homocysteine metabolism, may predispose to coronary artery disease (CAD). In a case-control study we determined the prevalence of two common MTHFR polymorphisms, C677T and A1298C, in 161 male patients under the age of 50 years with angiographically documented CAD and compared it to that in 211 healthy controls....
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