Article
Identification of six methylenetetrahydrofolate reductase (MTHFR) genotypes resulting from common polymorphisms: impact on plasma homocysteine levels and development of coronary artery disease.
Atherosclerosis - 15 Feb 2001
Meisel C, Cascorbi I, Gerloff T, Stangl V, Laule M, Müller J M, Wernecke K D, Baumann G, Roots I, Stangl K
Abstract excerpt
Although three common MTHFR polymorphisms (C677T, A1298C, T1317C) have been reported, only polymorphism C677T has been investigated intensively as a risk factor for coronary artery disease (CAD). We investigated polymorphism frequencies, allelic associations and the effect of the resulting MTHFR genotypes on total plasma homocysteine (tHcy) levels and on coronary risk in a case-control study with 1000...
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