Article
Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction.
Atherosclerosis - 1 Sept 2008
Rallidis Loukianos S, Gialeraki Argiro, Komporozos Christoforos, Vavoulis Panagiotis, Pavlakis Georgios, Travlou Anthi, Lekakis Ioannis, Kremastinos Dimitrios T
Abstract excerpt
BACKGROUND: The pathogenetic mechanism of premature myocardial infarction (MI) remains unknown. We explored the association of homocysteine and its main genetic modulator methylenetetrahydrofolate reductase (MTHFR) 677C->T polymorphism with the development of MI <or=35 years of age. METHODS: We performed a case-control study of 147 patients with a first MI <or=35 years and 103 age and sex-matched controls. We...
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