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Article

A common mutation in the methylenetetrahydrofolate reductase gene and risk of coronary heart disease: results among U.S. men.

Journal of the American College of Cardiology - 1 Aug 1998

Verhoef P, Rimm E B, Hunter D J, Chen J, Willett W C, Kelsey K, Stampfer M J

Abstract excerpt

OBJECTIVES: We examined the risk of coronary heart disease associated with homozygosity for the C677T mutation in the methylenetetrahydrofolate reductase gene. BACKGROUND: The mutation increases plasma homocysteine levels by impairing its remethylation. Increased plasma homocysteine is an independent risk factor for cardiovascular disease. METHODS: This was a case-control study nested within the Health...

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Identifiers

PMID: 9708460
DOI: 10.1016/s0735-1097(98)00244-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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