A common mutation in the methylenetetrahydrofolate reductase gene and risk of coronary heart disease: results among U.S. men.

doi:10.1016/s0735-1097(98)00244-7

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Article

A common mutation in the methylenetetrahydrofolate reductase gene and risk of coronary heart disease: results among U.S. men.

Journal of the American College of Cardiology - 1 Aug 1998

Verhoef P, Rimm E B, Hunter D J, Chen J, Willett W C, Kelsey K, Stampfer M J

Abstract excerpt

OBJECTIVES: We examined the risk of coronary heart disease associated with homozygosity for the C677T mutation in the methylenetetrahydrofolate reductase gene. BACKGROUND: The mutation increases plasma homocysteine levels by impairing its remethylation. Increased plasma homocysteine is an indepen...

Topics

Adult
Aged
Alleles
Case-Control Studies
Confidence Intervals
Coronary Disease
Diet
Folic Acid
Follow-Up Studies
Genotype
Heterozygote
Homocysteine
Homozygote
Humans
Male
Methionine
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 9708460
DOI: 10.1016/s0735-1097(98)00244-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9708460-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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