Article
Relation of a common mutation in methylenetetrahydrofolate reductase to plasma homocysteine and early onset coronary artery disease.
Clinical biochemistry - 1 Mar 1998
Dunn J, Title L M, Bata I, Johnstone D E, Kirkland S A, O'Neill B J, Zayed E, MacDonald M C, Dempsey G, Nassar B
Abstract excerpt
OBJECTIVE: In the presence of low serum folate, mutant 5,20-methylenetetrahydrofolate reductase (MTHFR + [A223V/C677T]) in the homozygous state (+/+), may predispose to higher plasma homocysteine (tHct) levels and coronary artery disease (CAD). To determine the impact of this relationship on predisposition to early-onset CAD, we examined the prevalence of the mutation and plasma tHct in patients with early-onset...
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