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Article

Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes.

The American journal of cardiology - 15 Jun 2005

Mager Aviv, Koren-Morag Nira, Shohat Mordechai, Harell Daniella, Battler Alexander

Abstract excerpt

A high plasma homocysteine level is associated with early onset of coronary artery disease (CAD), particularly in homozygotes for the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene. Family history is a predictor of increased plasma homocysteine and may be involved in early...

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Source

Identifiers

PMID: 15950563
DOI: 10.1016/j.amjcard.2005.01.097

Genes

CAD
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15950563-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes.PMID 15950563Read ↗

Plasma homocysteine, methylenetetrahydrofolate reductase genotypes, and age at onset of symptoms of myocardial ischemia.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease.Semantic proximity Read ↗

Correlation between C677T MTHFR gene polymorphism, plasma homocysteine levels and the incidence of CAD.Semantic proximity Read ↗

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Impact of ethnicity and MTHFR genotype on age at onset of coronary artery disease in women in Israel.Semantic proximity Read ↗

High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes.Semantic proximity Read ↗

Relation of a common mutation in methylenetetrahydrofolate reductase to plasma homocysteine and early onset coronary artery disease.Semantic proximity Read ↗

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Impact of homocysteine-lowering vitamin therapy on long-term outcome of patients with coronary artery disease.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease.Semantic proximity Read ↗

Homozygosity of the TT methylenetetrahydrofolate reductase C677T genotype is an independent long-term predictor of cardiac death in patients with premature myocardial infarction.Semantic proximity Read ↗

Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease.Semantic proximity Read ↗

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