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Article

Sympathoadrenal hyperplasia causes renal malformations in Ret(MEN2B)-transgenic mice.

The American journal of pathology - 1 Dec 1999

Gestblom C, Sweetser D A, Doggett B, Kapur R P

Abstract excerpt

The tyrosine kinase receptor Ret is expressed in the ureteric bud and is required for normal renal development. Constitutive loss of Ret, its co-receptor gfralpha-1, or the ligand glial cell line-derived neurotrophic factor results in renal agenesis. Transgenic embryos that express a constitutively active form of Ret (Ret(MEN2B)) under the control of the dopamine-beta-hydroxylase (DbetaH) promoter develop...

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Share to Adrenal Glands
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Source

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Identifiers

PMID: 10595945
DOI: 10.1016/S0002-9440(10)65534-4
PMCID: PMC1866938

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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