Article
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.
Nature - 27 Jan 1994
Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V
Abstract excerpt
Receptor tyrosine kinases (RTKs) are cell-surface molecules that transduce signals for cell growth and differentiation. The RTK encoded by the c-ret proto-oncogene is rearranged and constitutively activated in a large proportion of thyroid papillary carcinomas, and germ-line point mutations in c-ret seem to be responsible for the dominantly inherited cancer syndromes multiple endocrine neoplasia (MEN) types 2A...
Topics
- Animals
- Chimera
- Drosophila Proteins
- Enteric Nervous System
- Female
- Germ-Line Mutation
- Heterozygote
- Homozygote
- Intestines
- Kidney
- Male
- Mice