Article
C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B.
The EMBO journal - 15 Feb 2000
Smith-Hicks C L, Sizer K C, Powers J F, Tischler A S, Costantini F
Abstract excerpt
Dominantly inherited multiple endocrine neoplasia type 2B (MEN2B) is characterized by tumors of the thyroid C-cells and adrenal chromaffin cells, together with ganglioneuromas of the gastrointestinal tract and other developmental abnormalities. Most cases are caused by substitution of threonine for Met918 in the RET receptor tyrosine kinase, which is believed to convert the RET gene to an oncogene by altering the...
Topics
- Adrenal Gland Neoplasms
- Adrenal Glands
- Animals
- Base Sequence
- DNA Primers
- Disease Models, Animal
- Drosophila Proteins
- Female
- Ganglia, Sympathetic
- Ganglioneuroma
- Germ-Line Mutation
- Humans
- Hyperplasia
- Infertility, Male