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Article

Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice.

Kidney international - 1 Jul 2001

Cullen-McEwen L A, Drago J, Bertram J F

Abstract excerpt

BACKGROUND: The exact molecular mechanisms that regulate ureteric branching morphogenesis in the developing metanephros have not been fully elucidated. However, in vivo and in vitro evidence indicates that glial cell line-derived neurotrophic factor (GDNF) is a key regulator of the initiation of ureteric branching. GDNF knockout mice show renal agenesis or severe dysgenesis and die 24 hours after birth from renal...

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Source

Identifiers

PMID: 11422733
DOI: 10.1046/j.1523-1755.2001.00767.x

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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