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Article

Two common, functional polymorphisms in the promoter region of the beta-fibrinogen gene contribute to regulation of plasma fibrinogen concentration.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 1999

van 't Hooft F M, von Bahr S J, Silveira A, Iliadou A, Eriksson P, Hamsten A

Abstract excerpt

Plasma fibrinogen is a major risk factor for coronary heart disease, stroke, and peripheral artery disease. There is evidence that genetic variation in the beta-fibrinogen gene contributes to the rate of synthesis of fibrinogen, but the molecular mechanism underlying the genetic heritability of the plasma fibrinogen concentration is largely unknown. We evaluated the physiological roles of 5 common nucleotide...

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PMID: 10591688
DOI: 10.1161/01.atv.19.12.3063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Two common, functional polymorphisms in the promoter region of the beta-fibrinogen gene contribute to regulation of plasma fibrinogen concentration.PMID 10591688Read ↗

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