Article
Does elevated plasma fibrinogen increase the risk of coronary heart disease? Evidence from a meta-analysis of genetic association studies.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2005
Smith George Davey, Harbord Roger, Milton Julie, Ebrahim Shah, Sterne Jonathan A C
Abstract excerpt
OBJECTIVE: The purpose of this study was to assess whether a genetic variant associated with higher fibrinogen levels is associated with increased coronary heart disease (CHD) risk, as a test of the causal influence of fibrinogen on CHD. METHODS AND RESULTS: We performed a meta-analysis of case-control and prospective studies of the G-455-->A and C-148-->T beta-fibrinogen promoter region variants, in relation to...
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