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Article

Fibrinogen gene regulation.

Thrombosis and haemostasis - 1 Sept 2012

Fish Richard J, Neerman-Arbez Marguerite

Abstract excerpt

The Aα, Bβ and γ polypeptide chains of fibrinogen are encoded by a three gene cluster on human chromosome four. The fibrinogen genes (FGB-FGA-FGG) are expressed almost exclusively in hepatocytes where their output is coordinated to ensure a sufficient mRNA pool for each chain and maintain an abundant plasma fibrinogen protein level. Fibrinogen gene expression is controlled by the activity of proximal promoters...

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Source

Identifiers

PMID: 22836683
DOI: 10.1160/TH12-04-0273

Genes

FGA
FGB
FGG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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