Article
A common mutation (G-455--> A) in the beta-fibrinogen promoter is an independent predictor of plasma fibrinogen, but not of ischemic heart disease. A study of 9,127 individuals based on the Copenhagen City Heart Study.
The Journal of clinical investigation - 15 Jun 1997
Tybjaerg-Hansen A, Agerholm-Larsen B, Humphries S E, Abildgaard S, Schnohr P, Nordestgaard B G
Abstract excerpt
A common mutation (G-455--> A) in the promoter region of the beta-fibrinogen gene has been associated with elevated plasma fibrinogen levels. Whether fibrinogen genotype affects plasma fibrinogen levels and risk of ischemic heart disease in the general population has not been studied. We investig...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Estrogen Replacement Therapy
- Female
- Fibrinogen
- Genotype
- Humans
- Male
- Menopause
- Middle Aged
- Mutation
- Myocardial Ischemia