Complex regulation of the immunoglobulin mu heavy-chain gene enhancer: microB, a new determinant of enhancer function.

doi:10.1128/mcb.10.6.3145-3154.1990

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Article

Complex regulation of the immunoglobulin mu heavy-chain gene enhancer: microB, a new determinant of enhancer function.

Molecular and cellular biology - 1 Jun 1990

Nelsen B, Kadesch T, Sen R

Abstract excerpt

The B-lymphocyte-specific activity of the immunoglobulin mu heavy-chain gene enhancer has been attributed to the octamer motif (ATTTGCAT) present within the enhancer that binds a B-cell-specific factor designated NF-A2/OTF-2. However, significant residual enhancer activity even after deletion of this element has suggested the presence of a second critical functional determinant. We have used deletion and...

Topics

Animals
B-Lymphocytes
Base Sequence
Cell Line
Chromosome Deletion
Cloning, Molecular
Enhancer Elements, Genetic
Gene Expression Regulation
Genes, Immunoglobulin
Immunoglobulin Heavy Chains
Immunoglobulin mu-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Plasmids

Restriction Mapping

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2111446
DOI: 10.1128/mcb.10.6.3145-3154.1990
PMCID: PMC360679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2111446-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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