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Article

Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates.

Antimicrobial agents and chemotherapy - 1 Jan 2009

Morgan-Linnell Sonia K, Becnel Boyd Lauren, Steffen David, Zechiedrich Lynn

Abstract excerpt

Fluoroquinolone MICs are increased through the acquisition of chromosomal mutations in the genes encoding gyrase (gyrA and gyrB) and topoisomerase IV (parC and parE), increased levels of the multidrug efflux pump AcrAB, and the plasmid-borne genes aac(6')-Ib-cr and the qnr variants in Escherichia...

Topics

Anti-Bacterial Agents
Ciprofloxacin
DNA Gyrase
DNA Topoisomerase IV
Escherichia coli
Fluoroquinolones
Gatifloxacin
Humans
Levofloxacin
Microbial Sensitivity Tests
Mutation
Norfloxacin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ofloxacin

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Open in PubMed Open full text

Identifiers

PMID: 18838592
DOI: 10.1128/AAC.00665-08
PMCID: PMC2612180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-18838592-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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