Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms of resistance to quinolones.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jul 2005

Jacoby George A

Abstract excerpt

The increased use of fluoroquinolones has led to increasing resistance to these antimicrobials, with rates of resistance that vary by both organism and geographic region. Resistance to fluoroquinolones typically arises as a result of alterations in the target enzymes (DNA gyrase and topoisomerase IV) and of changes in drug entry and efflux. Mutations are selected first in the more susceptible target: DNA gyrase,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Plasmids
Share to Quinolones
Share to Ciprofloxacin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Topoisomerase IV

Share to Drug Resistance, Bacterial

Share to Escherichia coli

Share to Escherichia coli Proteins

Share to Staphylococcus aureus

Source

Identifiers

PMID: 15942878
DOI: 10.1086/428052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of resistance to quinolones.PMID 15942878Read ↗

Mechanisms of drug resistance: quinolone resistance.Semantic proximity Read ↗

Mechanisms of resistance to fluoroquinolones.Semantic proximity Read ↗

Mechanisms of quinolone resistance.Semantic proximity Read ↗

Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.Semantic proximity Read ↗

Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.Semantic proximity Read ↗

Mechanisms of quinolone action and resistance: where do we stand?Semantic proximity Read ↗

Molecular mechanisms associated with quinolone resistance in Enterobacteriaceae: review and updateSemantic proximity Read ↗

Mechanism of action of and resistance to quinolones.Semantic proximity Read ↗

Quinolone resistance mechanisms in pneumococci.Semantic proximity Read ↗

[Mechanisms for the development of quinolone resistance].Semantic proximity Read ↗

Emerging Mechanisms of Fluoroquinolone ResistanceSemantic proximity Read ↗

Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.