Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors.

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Article

Reduced expression level of mgmt mRNA and beta-catenin gene mutation in rat colon tumors.

Anticancer research - 1 Jan 2000

Kinjo Tatsuya, Suzui Masumi, Morioka Takamitsu, Inamine Morihiko, Kaneshiro Tatsuya, Arakaki Junya, Chiba Itaru, Sunagawa Nao, Nishimaki Tadashi, Yoshimi Naoki

Abstract excerpt

BACKGROUND: O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein and protects DNA from the biological effects of alkylating carcinogens. The purpose of this study was to investigate the association between the mRNA expression level of the Mgmt gene and mutation of the beta-catenin gene in rat colon tumors induced by azoxymethane (AOM) plus dextran sulfate sodium (DSS). MATERIALS AND METHODS:...

Topics

Animals
Azoxymethane
Colonic Neoplasms
Dextran Sulfate
Male
Mutation
O(6)-Methylguanine-DNA Methyltransferase
RNA, Messenger
Rats
Rats, Inbred F344
beta Catenin

Source

Open in PubMed

Identifiers

PMID: 16886601

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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