Article
Germline mutations of p53 but not p16/CDKN2 or PTEN/MMAC1 tumor suppressor genes predispose to gliomas. The ANOCEF Group. Association des NeuroOncologues d'Expression Française.
Annals of neurology - 1 Dec 1999
Zhou X P, Sanson M, Hoang-Xuan K, Robin E, Taillandier L, He J, Mokhtari K, Cornu P, Delattre J Y, Thomas G, Hamelin R
Abstract excerpt
Constitutional DNA from 44 selected patients suspected of being genetically predisposed to develop astrocytic tumors was analyzed for germline mutations of the p53, p16, and PTEN genes. Six constitutional missense mutations of the p53 gene were identified (13.6%), but no mutations of the p16 and PTEN genes were found, suggesting that (1) germline p53 mutations contribute to a small portion of astrocytic tumors,...
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