Article
Lack of germ-line mutations of CDK4, p16(INK4A), and p15(INK4B) in families with glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 1997
Gao L, Liu L, van Meyel D, Cairncross G, Forsyth P, Kimmel D, Jenkins R B, Lassam N J, Hogg D
Abstract excerpt
Gliomas are tumors of the central nervous system that may be inherited in some patients. The gene(s) responsible for the clustering of gliomas in families have not yet been identified. Molecular studies of sporadic high-grade gliomas have revealed mutations or deletions of the genes encoding the...
Topics
- Adult
- Aged
- Base Sequence
- Brain Neoplasms
- Carrier Proteins
- Cell Cycle Proteins
- Cluster Analysis
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- DNA Primers
- Exons
- Family