Article
Lack of germ-line mutations of CDK4, p16(INK4A), and p15(INK4B) in families with glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 1997
Gao L, Liu L, van Meyel D, Cairncross G, Forsyth P, Kimmel D, Jenkins R B, Lassam N J, Hogg D
Abstract excerpt
Gliomas are tumors of the central nervous system that may be inherited in some patients. The gene(s) responsible for the clustering of gliomas in families have not yet been identified. Molecular studies of sporadic high-grade gliomas have revealed mutations or deletions of the genes encoding the protein kinase inhibitors p16(INK4A) and p15(INK4B) in a large proportion of tumors. Moreover, those tumors without...
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