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Article

Investigation of germline PTEN, p53, p16INK4A/p14ARF, and CDK4 alterations in familial glioma

15 May 2000

Abstract excerpt

Epidemiological studies suggest that some familial aggregations of glioma may be due to inherited predisposition. Many genes involved in familial cancers are frequently altered in the corresponding sporadic forms. We have investigated several genes known to be altered in sporadic gliomas for their potential contribution to familial glioma. Fifteen glioma patients with a family history of brain tumors were...

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Identifiers

PMID: 10797439
DOI: 10.1002/(sici)1096-8628(20000515)92:2<136::aid-ajmg11>3.0.co;2-s

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