Article
Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation.
Familial cancer - 1 Sept 2010
Robertson Lindsay B, Armstrong Georgina N, Olver Bianca D, Lloyd Amy L, Shete Sanjay, Lau Ching, Claus Elizabeth B, Barnholtz-Sloan Jill, Lai Rose, Il'yasova Dora, Schildkraut Joellen, Bernstein Jonine L, Olson Sara H, Jenkins Robert B, Yang Ping, Rynearson Amanda Lynn, Rynerason Amanda L, Wrensch Margaret, McCoy Lucie, Wienkce John K, McCarthy Bridget, Davis Faith, Vick Nicholas A, Johansen Christoffer, Bødtcher Hanne, Sadetzki Siegal, Bruchim Revital Bar-Sade, Yechezkel Galit Hirsh, Andersson Ulrika, Melin Beatrice S, Bondy Melissa L, Houlston Richard S
Abstract excerpt
There is increasing recognition of familial propensity to glioma as a distinct clinical entity beyond a few rare syndromes; however its genetic basis is poorly understood. The role of p16(INK4A)/p14(ARF) and p53 mutations in sporadic glioma provides a strong rationale for investigating germline mutations in these genes as a cause of familial glioma. To survey the familial glioma phenotype and examine the...
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