Article
Tumor genomic profiling and TP53 germline mutation analysis of first-degree relative familial gliomas.
Cancer genetics and cytogenetics - 15 Jul 2007
Idbaih Ahmed, Boisselier Blandine, Sanson Marc, Crinière Emmanuelle, Liva Stéphane, Marie Yannick, Carpentier Catherine, Paris Sophie, Laigle-Donadey Florence, Mokhtari Karima, Kujas Michèle, Hoang-Xuan Khê, Delattre Olivier, Delattre Jean-Yves
Abstract excerpt
About 5% of gliomas occur in a familial context, which suggests a genetic origin, but the predisposing molecular factors remain unknown in most cases. A series of nine familial gliomas were characterized with 1-megabase resolution BAC array-based comparative genomic hybridization (aCGH) together with germline sequence analysis of TP53. This series was compared with a literature series of familial gliomas and a...
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