Article
Immunosuppressant FK506 activates NF-kappaB through the proteasome-mediated degradation of IkappaBalpha. Requirement for Ikappabalpha n-terminal phosphorylation but not ubiquitination sites.
The Journal of biological chemistry - 3 Dec 1999
Zhang Y, Sun X, Muraoka K, Ikeda A, Miyamoto S, Shimizu H, Yoshioka K, Yamamoto K
Abstract excerpt
The immunosuppressant FK506 activates NF-kappaB through IkappaBalpha degradation in nonlymphoid cells. In the present study, we analyzed mechanisms by which FK506 induces IkappaBalpha degradation. We found that FK506 induces the degradation of both IkappaBalpha and IkappaBbeta and that the time courses of the FK506-induced degradation are quite different from degradation induced by interleukin 1 (IL-1). Despite...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.