Article
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
The Journal of biological chemistry - 19 Sept 2003
Sakurai Hiroaki, Suzuki Shunsuke, Kawasaki Noritaka, Nakano Hiroyasu, Okazaki Tatsuma, Chino Atsushi, Doi Takahiro, Saiki Ikuo
Abstract excerpt
The activation of NF-kappaB has been shown to be regulated by multiple phosphorylations of IkappaBs and the NF-kappaB p65 subunit. Here, we characterized the intracellular signaling pathway leading to phosphorylation of p65 on Ser-536 using a novel anti-phospho-p65 (Ser-536) antibody. The Ser-536 of endogenous p65 was rapidly phosphorylated in response to a wide variety of NF-kappaB stimulants including TNF-alpha...
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