Article
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation.
Science (New York, N.Y.) - 10 Mar 1995
Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U
Abstract excerpt
I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm. Various stimuli, typically those associated with stress or pathogens, rapidly inactivate I kappa B-alpha. This liberates NF-kappa B to translocate to the nucleus and initiate transcription of genes importan...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- DNA-Binding Proteins
- Humans
- I-kappa B Proteins
- Ionomycin
- Mice
- Molecular Sequence Data
- Mutation
- NF-KappaB Inhibitor alpha
- NF-kappa B
- Phosphorylation
- Point Mutation
- Signal Transduction
- T-Lymphocytes
- Tetradecanoylphorbol Acetate
- Transcriptional Activation