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Article

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation.

Science (New York, N.Y.) - 10 Mar 1995

Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U

Abstract excerpt

I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm. Various stimuli, typically those associated with stress or pathogens, rapidly inactivate I kappa B-alpha. This liberates NF-kappa B to translocate to the nucleus and initiate transcription of genes important for the defense of the organism. Activation of NF-kappa B correlates with phosphorylation of I kappa B-alpha and...

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Identifiers

PMID: 7878466
DOI: 10.1126/science.7878466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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