Article
IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.
Molecular and cellular biology - 1 May 1996
Klement J F, Rice N R, Car B D, Abbondanzo S J, Powers G D, Bhatt P H, Chen C H, Rosen C A, Stewart C L
Abstract excerpt
The ubiquitous transcription factor NF-kappaB is an essential component in signal transduction pathways, in inflammation, and in the immune response. NF-kappaB is maintained in an inactive state in the cytoplasm by protein-protein interaction with IkappaBalpha. Upon stimulation, rapid degradation...
Topics
- 3T3 Cells
- Animals
- Blotting, Western
- Cell Nucleus
- Cloning, Molecular
- Cycloheximide
- DNA-Binding Proteins
- Dermatitis
- Embryo, Mammalian
- Gene Expression
- Genetic Carrier Screening
- Genotype
- Homozygote
- I-kappa B Proteins
- Kidney