Article
IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.
Molecular and cellular biology - 1 May 1996
Klement J F, Rice N R, Car B D, Abbondanzo S J, Powers G D, Bhatt P H, Chen C H, Rosen C A, Stewart C L
Abstract excerpt
The ubiquitous transcription factor NF-kappaB is an essential component in signal transduction pathways, in inflammation, and in the immune response. NF-kappaB is maintained in an inactive state in the cytoplasm by protein-protein interaction with IkappaBalpha. Upon stimulation, rapid degradation of IkappaBalpha allows nuclear translocation of NF-kappaB. To study the importance of IkappaBalpha in signal...
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