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Article

Negative control of flagellum synthesis in Pseudomonas aeruginosa is modulated by the alternative sigma factor AlgT (AlgU).

Journal of bacteriology - 1 Dec 1999

Garrett E S, Perlegas D, Wozniak D J

Abstract excerpt

Many respiratory isolates of Pseudomonas aeruginosa from cystic fibrosis patients are mucoid (alginate producing) yet lack flagella. It was hypothesized that an alginate regulator inhibits flagellar gene expression. Mutations in algB, algR, and algT resulted in nonmucoid derivatives, yet algT mutants expressed flagella. AlgT-dependent control of flagellum synthesis occurred through inhibition of fliC but not rpoN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10572149
DOI: 10.1128/JB.181.23.7401-7404.1999
PMCID: PMC103708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Negative control of flagellum synthesis in Pseudomonas aeruginosa is modulated by the alternative sigma factor AlgT (AlgU).PMID 10572149Read ↗

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A molecular mechanism for how sigma factor AlgT and transcriptional regulator AmrZ inhibit twitching motility in Pseudomonas aeruginosaSemantic proximity Read ↗

A mutation in algN permits trans activation of alginate production by algT in Pseudomonas species.Semantic proximity Read ↗

A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.Semantic proximity Read ↗

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Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients.Semantic proximity Read ↗

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