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Evidence for Sigma Factor Competition in the Regulation of Alginate Production by Pseudomonas aeruginosa

22 Aug 2013

Abstract excerpt

Alginate overproduction, or mucoidy, plays an important role in the pathogenesis of P. aeruginosa lung infection in cystic fibrosis (CF). Mucoid strains with mucA mutations predominantly populate in chronically-infected patients. However, the mucoid strains can revert to nonmucoidy in vitro through suppressor mutations. We screened a mariner transposon library using CF149, a non-mucoid clinical isolate with a...

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PMID: 23991093
DOI: 10.1371/journal.pone.0072329

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Evidence for Sigma Factor Competition in the Regulation of Alginate Production by Pseudomonas aeruginosaPMID 23991093Read ↗

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