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The Alternative Sigma Factor AlgT RepressesPseudomonas aeruginosaFlagellum Biosynthesis by Inhibiting Expression offleQ

16 Nov 2005

Abstract excerpt

Pseudomonas aeruginosa poses a serious risk in individuals suffering from cystic fibrosis (CF). Strains colonizing the CF lung are generally motile but frequently convert to a nonmotile phenotype as the disease progresses. In many cases, this is coordinately regulated with the overproduction of the exopolysaccharide alginate. Both the expression of alginate (mucoidy) and the loss of flagellum synthesis may...

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PMID: 16291668
DOI: 10.1128/jb.187.23.7955-7962.2005

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Click a neighbor to travelStep 1 · 12 closest

The Alternative Sigma Factor AlgT RepressesPseudomonas aeruginosaFlagellum Biosynthesis by Inhibiting Expression offleQPMID 16291668Read ↗

Negative control of flagellum synthesis in Pseudomonas aeruginosa is modulated by the alternative sigma factor AlgT (AlgU).Semantic proximity Read ↗

Mucoid-to-nonmucoid conversion in alginate-producing Pseudomonas aeruginosa often results from spontaneous mutations in algT, encoding a putative alternate sigma factor, and shows evidence for autoregulation.Semantic proximity Read ↗

Overproduction of the AlgT Sigma Factor Is Lethal to Mucoid Pseudomonas aeruginosa.Semantic proximity Read ↗

The algT (algU) gene of Pseudomonas aeruginosa, a key regulator involved in alginate biosynthesis, encodes an alternative sigma factor (sigma E).Semantic proximity Read ↗

Overproduction of the AlgT sigma factor is lethal to mucoid <i>Pseudomonas aeruginosa</i>Semantic proximity Read ↗

Expression of mucoid induction factor MucE is dependent upon the alternate sigma factor AlgU in Pseudomonas aeruginosaSemantic proximity Read ↗

A mutation in algN permits trans activation of alginate production by algT in Pseudomonas species.Semantic proximity Read ↗

Lipotoxin F of Pseudomonas aeruginosa is an AlgU-dependent and alginate-independent outer membrane protein involved in resistance to oxidative stress and adhesion to A549 human lung epitheliaSemantic proximity Read ↗

Pseudomonas aeruginosa flagellin and alginate elicit very distinct gene expression patterns in airway epithelial cells: implications for cystic fibrosis disease.Semantic proximity Read ↗

A molecular mechanism for how sigma factor AlgT and transcriptional regulator AmrZ inhibit twitching motility in Pseudomonas aeruginosaSemantic proximity Read ↗

The Transcriptional Regulator AlgR Is Essential for Pseudomonas aeruginosa PathogenesisSemantic proximity Read ↗

Sigma factor-anti-sigma factor interaction in alginate synthesis: inhibition of AlgT by MucA.Semantic proximity Read ↗

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