Article
Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1993
Martin D W, Schurr M J, Mudd M H, Govan J R, Holloway B W, Deretic V
Abstract excerpt
Chronic respiratory infections with mucoid Pseudomonas aeruginosa are the leading cause of high mortality and morbidity in cystic fibrosis (CF). The initially colonizing strains are nonmucoid, but in the CF lung they invariably convert into the mucoid, exopolysaccharide alginate-overproducing for...
Topics
- Alginates
- Alleles
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- Cystic Fibrosis
- Genes, Bacterial
- Genetic Complementation Test
- Glucuronic Acid
- Hexuronic Acids
- Humans
- Molecular Sequence Data
- Multigene Family
- Mutagenesis
- Oligodeoxyribonucleotides