Article
Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1993
Martin D W, Schurr M J, Mudd M H, Govan J R, Holloway B W, Deretic V
Abstract excerpt
Chronic respiratory infections with mucoid Pseudomonas aeruginosa are the leading cause of high mortality and morbidity in cystic fibrosis (CF). The initially colonizing strains are nonmucoid, but in the CF lung they invariably convert into the mucoid, exopolysaccharide alginate-overproducing form causing further deterioration and poor prognosis. Here we report the molecular basis of conversion to mucoidy. The...
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