Article

Overproduction of the AlgT sigma factor is lethal to mucoid <i>Pseudomonas aeruginosa</i>

2020-06-06

Abstract excerpt

<h4>ABSTRACT</h4> Pseudomonas aeruginosa isolates from chronic lung infections often overproduce alginate, giving rise to the mucoid phenotype. Isolation of mucoid strains from chronic lung infections correlates with a poor patient outcome. The most common mutation that causes the mucoid phenotype is called mucA22 and results in a truncated form of the anti-sigma factor MucA that is continuously subjected to pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 709fa242-9997-5f16-b0a5-ad06fd5c4c30
DOI: 10.1101/2020.06.05.136770

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overproduction of the AlgT sigma factor is lethal to mucoid <i>Pseudomonas aeruginosa</i>DOI 10.1101/2020.06.05.136770Read

Overproduction of the AlgT Sigma Factor Is Lethal to Mucoid Pseudomonas aeruginosa.Semantic proximity Read

The anti-sigma factor MucA is required for viability in <i>Pseudomonas aeruginosa</i>Semantic proximity Read

In vivo and in vitro analyses of the role of the Prc protease in inducing mucoidy in Pseudomonas aeruginosa.Semantic proximity Read

Proteolytic regulation of alginate overproduction in <i>Pseudomonas aeruginosa</i>Semantic proximity Read

ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa.Semantic proximity Read

Truncation of type IV pilin induces mucoidy in Pseudomonas aeruginosa strain PAO579.Semantic proximity Read

Sigma factor-anti-sigma factor interaction in alginate synthesis: inhibition of AlgT by MucA.Semantic proximity Read

Expression of mucoid induction factor MucE is dependent upon the alternate sigma factor AlgU in Pseudomonas aeruginosaSemantic proximity Read

Prc protease promotes mucoidy in mucA mutants of Pseudomonas aeruginosa.Semantic proximity Read

The Pseudomonas aeruginosa homeostasis enzyme AlgL clears the periplasmic space of accumulated alginate during polymer biosynthesisSemantic proximity Read

Mucoid-to-nonmucoid conversion in alginate-producing Pseudomonas aeruginosa often results from spontaneous mutations in algT, encoding a putative alternate sigma factor, and shows evidence for autoregulation.Semantic proximity Read

A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.Semantic proximity Read