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Article

A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.

Gene - 1 May 2012

Sautter Robert, Ramos Damaris, Schneper Lisa, Ciofu Oana, Wassermann Tina, Koh Chong-Lek, Heydorn Arne, Hentzer Morton, Høiby Niels, Kharazmi Arsalan, Molin Søren, Devries Caroline A, Ohman Dennis E, Mathee Kalai

Abstract excerpt

Infection by the opportunistic pathogen Pseudomonas aeruginosa is a leading cause of morbidity and mortality seen in cystic fibrosis (CF) patients. This is mainly due to the genotypic and phenotypic changes of the bacteria that cause conversion from a typical nonmucoid to a mucoid form in the CF lung. Mucoid conversion is indicative of overproduction of a capsule-like polysaccharide called alginate. The...

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Identifiers

PMID: 22088575
DOI: 10.1016/j.gene.2011.11.005
PMCID: PMC4968699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.PMID 22088575Read ↗

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Outer-membrane protein LptD (PA0595) plays a role in the regulation of alginate synthesis in Pseudomonas aeruginosa.Semantic proximity Read ↗

Gene cluster controlling conversion to alginate-overproducing phenotype in Pseudomonas aeruginosa: functional analysis in a heterologous host and role in the instability of mucoidy.Semantic proximity Read ↗

Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.Semantic proximity Read ↗

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