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Article

Overexpression of a dominant-negative allele of SEC4 inhibits growth and protein secretion in Candida albicans.

Journal of bacteriology - 1 Dec 1999

Mao Y, Kalb V F, Wong B

Abstract excerpt

Candida albicans SEC4 was cloned by complementing the Saccharomyces cerevisiae sec4-8 mutation, and its deduced protein product (Sec4p) was 63% identical to S. cerevisiae Sec4p. One chromosomal SEC4 allele in C. albicans CAI4 was readily disrupted by homologous gene targeting, but efforts to disrupt the second allele yielded no viable null mutants. Although this suggested that C. albicans SEC4 was essential, it...

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Identifiers

PMID: 10572126
DOI: 10.1128/JB.181.23.7235-7242.1999
PMCID: PMC103685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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