Article
The Candida albicans Exocyst Subunit Sec6 Contributes to Cell Wall Integrity and Is a Determinant of Hyphal Branching.
Eukaryotic cell - 1 Jul 2015
Chavez-Dozal Alba A, Bernardo Stella M, Rane Hallie S, Herrera Gloria, Kulkarny Vibhati, Wagener Jeanette, Cunningham Iain, Brand Alexandra C, Gow Neil A R, Lee Samuel A
Abstract excerpt
The yeast exocyst is a multiprotein complex comprised of eight subunits (Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84) which orchestrates trafficking of exocytic vesicles to specific docking sites on the plasma membrane during polarized secretion. To study SEC6 function in Candida albicans, we generated a conditional mutant strain in which SEC6 was placed under the control of a tetracycline-regulated...
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