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Article

Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct.

The Journal of biological chemistry - 15 Nov 1996

Mullins C, Meyer H A, Hartmann E, Green N, Fang H

Abstract excerpt

Two subunits of the mammalian signal peptidase complex, SPC12 and SPC25, share similar membrane topologies with the majority of each protein oriented toward the cytoplasm. Such similarities may suggest that these proteins perform redundant functions in signal peptidase activity. In the present study, we addressed this issue through analysis of the yeast homologs to SPC12 and SPC25, Spc1p and Spc2p. We show that...

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Source

Identifiers

PMID: 8910564
DOI: 10.1074/jbc.271.46.29094

Genes

SPC25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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