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Article

Candida albicans VPS4 is required for secretion of aspartyl proteases and in vivo virulence.

Mycopathologia - 1 Feb 2009

Lee Samuel A, Jones Jason, Hardison Sarah, Kot John, Khalique Zachary, Bernardo Stella M, Lazzell Anna, Monteagudo Carlos, Lopez-Ribot Jose

Abstract excerpt

Candida albicans secretes aspartyl proteases (Saps) during infection. Although Saps are secretory proteins, little is known about the intracellular trafficking and secretion of these proteins. We previously cloned and analyzed the C. albicans pre-vacuolar protein sorting gene VPS4, and demonstrated that extracellular Sap2p is absent in the culture supernatants of the vps4delta null mutant. We therefore...

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Identifiers

PMID: 18814053
DOI: 10.1007/s11046-008-9155-7
PMCID: PMC5898969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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