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Article

Inhibition of cardiac delayed rectifier K+ current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice.

Circulation research - 21 Sept 1998

Babij P, Askew G R, Nieuwenhuijsen B, Su C M, Bridal T R, Jow B, Argentieri T M, Kulik J, DeGennaro L J, Spinelli W, Colatsky T J

Abstract excerpt

Mutations in the HERG gene are linked to the LQT2 form of the inherited long-QT syndrome. Transgenic mice were generated expressing high myocardial levels of a particularly severe form of LQT2-associated HERG mutation (G628S). Hearts from G628S mice appeared normal except for a modest enlargement seen only in females. Ventricular myocytes isolated from adult wild-type hearts consistently exhibited an inwardly...

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Identifiers

PMID: 9742063
DOI: 10.1161/01.res.83.6.668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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