Article
Inhibition of cardiac delayed rectifier K+ current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice.
Circulation research - 21 Sept 1998
Babij P, Askew G R, Nieuwenhuijsen B, Su C M, Bridal T R, Jow B, Argentieri T M, Kulik J, DeGennaro L J, Spinelli W, Colatsky T J
Abstract excerpt
Mutations in the HERG gene are linked to the LQT2 form of the inherited long-QT syndrome. Transgenic mice were generated expressing high myocardial levels of a particularly severe form of LQT2-associated HERG mutation (G628S). Hearts from G628S mice appeared normal except for a modest enlargement...
Topics
- Action Potentials
- Animals
- Cation Transport Proteins
- DNA-Binding Proteins
- Delayed Rectifier Potassium Channels
- Disease Models, Animal
- ERG1 Potassium Channel
- Electrocardiography
- Ether-A-Go-Go Potassium Channels
- Female