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Article

Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression.

The Journal of clinical investigation - 1 May 2003

Miake Junichiro, Marbán Eduardo, Nuss H Bradley

Abstract excerpt

The inward rectifier current I(K1) is tightly regulated regionally within the heart, downregulated in heart failure, and genetically suppressed in Andersen syndrome. We used in vivo viral gene transfer to dissect the role of I(K1) in cardiac repolarization and maintenance of the resting membrane potential (RMP) in guinea pig ventricular myocytes. Kir2.1 overexpression boosted Ba(2+)-sensitive I(K1) by more than...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12750402
DOI: 10.1172/JCI17959
PMCID: PMC155052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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