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Article

Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.

International journal of oncology - 1 Dec 1999

Sakurada A, Hamada H, Fukushige S, Yokoyama T, Yoshinaga K, Furukawa T, Sato S, Yajima A, Sato M, Fujimura S, Horii A

Abstract excerpt

PTEN, a gene encoding a dual specificity phosphatase, is frequently altered in endometrial carcinoma. Moreover, these alterations are observed even in atypical hyperplasia of the endometrium. This evidence suggests that mutation of PTEN is an early genetic alteration involved in endometrial carcinogenesis. Adenovirus-mediated gene transfer was carried out using Ishikawa 3 H 12 and RL95-2, the endometrial cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10568810
DOI: 10.3892/ijo.15.6.1069

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.PMID 10568810Read ↗

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Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.Semantic proximity Read ↗

PI3K/PTEN/AKT Genetic Mouse Models of Endometrial Carcinoma.Semantic proximity Read ↗

In Vitro and In Vivo Effects of Tumor Suppressor Gene PTEN on Endometriosis: An Experimental StudySemantic proximity Read ↗

Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells.Semantic proximity Read ↗

Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene.Semantic proximity Read ↗

Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?Semantic proximity Read ↗

ERBB2 Targeting Reveals a Significant Suppression of Tumorigenesis in Murine Endometrial Cancer with Pten Mutation.Semantic proximity Read ↗

The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.Semantic proximity Read ↗

Loss of PTEN expression is an independent predictor of favourable survival in endometrial carcinomasSemantic proximity Read ↗

PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells.Semantic proximity Read ↗

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