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Article

Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells.

British journal of cancer - 15 Nov 2004

Jin X, Gossett D R, Wang S, Yang D, Cao Y, Chen J, Guo R, Reynolds R K, Lin J

Abstract excerpt

The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumour suppressor is mutated in 40-50% of human endometrial cancers. PTEN exerts its effects in part via inhibition of the antiapoptotic protein AKT. We demonstrate that two endometrial cancer cell lines that harbour PTEN mutations, Ishikawa and RL95-2, have high levels of phosphorylated AKT and high AKT kinase activity. Two additional endometrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15505622
DOI: 10.1038/sj.bjc.6602214
PMCID: PMC2410058

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells.PMID 15505622Read ↗

Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells.Semantic proximity Read ↗

Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1.Semantic proximity Read ↗

PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway.Semantic proximity Read ↗

Activation of PI3K/Akt/mTOR pathway and dual inhibitors of PI3K and mTOR in endometrial cancer.Semantic proximity Read ↗

Molecular alterations of PI3K/Akt/mTOR pathway: a therapeutic target in endometrial cancer.Semantic proximity Read ↗

Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.Semantic proximity Read ↗

Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.Semantic proximity Read ↗

Somatic mutations are present in all members of the AKT family in endometrial carcinomaSemantic proximity Read ↗

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PI3K pathway dependencies in endometrioid endometrial cancer cell lines.Semantic proximity Read ↗

Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.Semantic proximity Read ↗

Combined PI3K Inhibitor and Eribulin Enhances Anti-Tumor Activity in Preclinical Models of Paclitaxel-Resistant, PIK3CA-Mutated Endometrial CancerSemantic proximity Read ↗

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