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Article

Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells.

Anticancer research - 1 Jan 2000

Lilja J F, Wu D, Reynolds R K, Lin J

Abstract excerpt

The AKT proteins are constitutively activated in several types of human cancers, which may play a role in carcinogenesis. In this study, we examined the activation of AKT in a panel of human endometrial cancer cell lines and tumor samples in this study. Two endometrial cancer cell lines, Ishikawa (ISK) and RL-95 and several tumor samples showed elevated levels of phosphorylated AKT PTEN, which is mutated in 45%...

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Share to beta Catenin
Share to Calcium-Calmodulin-Dependent Protein Kinases
Share to Endometrial Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to Phosphoric Monoester Hydrolases

Share to Proto-Oncogene Proteins c-akt

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Share to PTEN Phosphohydrolase

Source

Identifiers

PMID: 11497285

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells.PMID 11497285Read ↗

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Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.Semantic proximity Read ↗

Activation of PI3K/Akt/mTOR pathway and dual inhibitors of PI3K and mTOR in endometrial cancer.Semantic proximity Read ↗

Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.Semantic proximity Read ↗

ERBB2 Targeting Reveals a Significant Suppression of Tumorigenesis in Murine Endometrial Cancer with Pten Mutation.Semantic proximity Read ↗

Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.Semantic proximity Read ↗

Somatic mutations are present in all members of the AKT family in endometrial carcinomaSemantic proximity Read ↗

Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.Semantic proximity Read ↗

The biology and clinical relevance of the PTEN tumor suppressor pathway.Semantic proximity Read ↗

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