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Article

PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells.

Cancer research - 1 Jun 2001

Zhu X, Kwon C H, Schlosshauer P W, Ellenson L H, Baker S J

Abstract excerpt

Inactivating mutations in the PTEN tumor suppressor gene occur in approximately 30-50% of endometrial carcinomas. PTEN is a phosphatase that negatively regulates the phosphoinositide 3-kinase signaling pathway, including the downstream effector AKT. To evaluate the role of PTEN in endometrial gro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11389092

Genes

PTEN
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11389092-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells.PMID 11389092Read ↗

Growth suppression activity of the PTEN tumor suppressor gene in human endometrial cancer cells.Semantic proximity Read ↗

PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.Semantic proximity Read ↗

Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1.Semantic proximity Read ↗

Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion.Semantic proximity Read ↗

Molecular alterations of PI3K/Akt/mTOR pathway: a therapeutic target in endometrial cancer.Semantic proximity Read ↗

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.Semantic proximity Read ↗

PI3K pathway in gynecologic malignancies.Semantic proximity Read ↗

Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?Semantic proximity Read ↗

PI3K/PTEN/AKT Genetic Mouse Models of Endometrial Carcinoma.Semantic proximity Read ↗

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten+/- mice.Semantic proximity Read ↗

Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.Semantic proximity Read ↗

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice.Semantic proximity Read ↗

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