Article
PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells.
Cancer research - 1 Jun 2001
Zhu X, Kwon C H, Schlosshauer P W, Ellenson L H, Baker S J
Abstract excerpt
Inactivating mutations in the PTEN tumor suppressor gene occur in approximately 30-50% of endometrial carcinomas. PTEN is a phosphatase that negatively regulates the phosphoinositide 3-kinase signaling pathway, including the downstream effector AKT. To evaluate the role of PTEN in endometrial growth regulation, we expressed wild-type or mutant PTEN in endometrial carcinoma cell lines. As expected, expression of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.