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Article

Reversal of the malignant phenotype of ovarian cancer A2780 cells through transfection with wild-type PTEN gene.

Cancer letters - 28 Nov 2008

Wu Huijuan, Wang Shixuan, Weng Danghui, Xing Hui, Song Xiaohong, Zhu Tao, Xia Xi, Weng Yanjie, Xu Gang, Meng Li, Zhou Jianfeng, Ma Ding

Abstract excerpt

OBJECTIVE: PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a tumor suppressor gene identified on human chromosome 10q23. Substantial studies have demonstrated that PTEN can inhibit cell proliferation, migration and invasion of many cancer cells. The purpose of this study was to determine whether upregulation of PTEN gene by transfection wild-type PTEN gene to ovarian cancer cells can inhibit...

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Identifiers

PMID: 18662848
DOI: 10.1016/j.canlet.2008.06.018

Genes

PTEN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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