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Article

Mismatch Repair Processing of Carcinogen-DNA Adducts Triggers Apoptosis

1 Dec 1999

Abstract excerpt

The DNA mismatch repair pathway is well known for its role in correcting biosynthetic errors of DNA replication. We report here a novel role for mismatch repair in signaling programmed cell death in response to DNA damage induced by chemical carcinogens. Cells proficient in mismatch repair were highly sensitive to the cytotoxic effects of chemical carcinogens, while cells defective in either human MutS or MutL...

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PMID: 10567554
DOI: 10.1128/mcb.19.12.8292

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